Can you overdose on cannabis? No. The number of people who have died due to cannabis overdose, in all of recorded history, is zero.
That’s one of the most well-known facts in the cannabis library. But is it really true? And if so, why?
Yes, it’s true. Cannabis itself cannot kill the human body. But let’s be clear: It is very possible to “overdose” on cannabis in the sense of overconsumption. Most experienced cannabis consumers have, at one point or another, gotten themselves to a place they didn’t want to be. You didn’t check the dosage on that edible, and now you’re regretting it. You’re uncomfortable. You may be feeling downright miserable. It’s okay. You’re not going to die. It will pass. Lesson learned.
Why is that, exactly?
It’s possible to die from opioid overdose or alcohol poisoning. But cannabis acts on the body and mind in a way that’s very different than opioids or alcohol.
We’re all familiar with the tragic phrase “died of an overdose,” but when opioids like fentanyl, Oxycontin, or heroin are the cause, there’s a specific mechanism that leads to death. As Oxford University anesthesiology professor K.T.S. Pattinson has observed, “In drug addicts, respiratory depression is the major cause of death.” In other words, during an opioid overdose the victim falls unconscious and the body forgets to breathe.
Opioid receptors are found in many areas of the brain, including the pre-Bötzinger complex in the brainstem, which controls breathing. This is a major reason why opioid overdose can be deadly, as opioids affect this critical brainstem region.
In some cases, an opioid overdose can also depress the brain’s mechanism that regulates the heart and blood circulation, leading to a drop in blood pressure and heart failure. Alcohol poisoning can become lethal when the alcohol overwhelms the liver’s ability to clear it, and alcohol in the blood anesthetizes those same brain systems that regulate breathing and blood pressure. They shut down, which leads to death.